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Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C.

Samuel D ShinAlexandra ShinKarina MayagoitiaLorraine SieboldMarsilio RubiniChristopher G WilsonDenise L BellingerSalvador Soriano
Published in: Journal of neuroinflammation (2019)
Loss of APP exacerbates the pathogenic neuroinflammation that occurs prior to symptomatic onset in the NPC brain. These findings shed new light on the function of APP as a cytoprotective modulator in the CNS, offering potential evidence-based therapies against NPC.
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