Methadone-associated QT interval prolongation in patients undergoing maintenance therapy in an urban opioid treatment program.

Erika N Titus-LayHeather A JaynesElena Tomaselli MuenstermanTodd A WalrothCarol A OttZeruesenay DestaGabriela WilliamsPaul R MoeMichelle WilbrandtJames E Tisdale

Published in: Pharmacotherapy (2021)

Approximately 15% of patients taking maintenance methadone therapy developed QT interval prolongation. Both serum (S)- and (R)-methadone concentrations, but not (S)- or (R)-EDDP, contribute to methadone-associated QT prolongation.

Keyphrases

drug induced
patients undergoing
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
chronic pain
prognostic factors
pain management
mesenchymal stem cells
bone marrow
chemotherapy induced