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A single-shot vaccine approach for the universal influenza A vaccine candidate M2e.

Ranmali KavishnaTha Yang KangMaurizio VaccaBenson Yen Leong ChuaHae-Young ParkPeck Szee TanVincent Tak Kwong ChowMireille H LahoudSylvie Alonso
Published in: Proceedings of the National Academy of Sciences of the United States of America (2022)
SignificanceAlthough the need for a universal influenza vaccine has long been recognized, only a handful of candidates have been identified so far, with even fewer advancing in the clinical pipeline. The 24-amino acid ectodomain of M2 protein (M2e) has been developed over the past two decades. However, M2e-based vaccine candidates have shortcomings, including the need for several administrations and the lack of sustained antibody titers over time. We report here a vaccine targeting strategy that has the potential to confer sustained and strong protection upon a single shot of a small amount of M2e antigen. The current COVID-19 pandemic has highlighted the importance of developing versatile, powerful platforms for the rapid deployment of vaccines against any incoming threat.
Keyphrases
  • amino acid
  • protein protein