Serum alpha-CGRP levels are increased in COVID-19 patients with headache indicating an activation of the trigeminal system.

Gabriel GárateMaría TorielloVicente González-QuintanillaSara Pérez-PeredaJorge MaderaMarta PascualJosé Manuel OlmosJulio Pascual

Published in: BMC neurology (2023)

CGRP levels are increased in COVID-19 patients experiencing headache in the acute phase of this disease, which could explain why headache frequently occurs in COVID-19 and strongly supports a role for trigeminal activation in the pathophysiology of headache in this viral infection.

Keyphrases

sars cov
coronavirus disease
neuropathic pain
respiratory syndrome coronavirus
spinal cord