Value of DNA testing in the diagnosis of sickle-cell anemia in childhood in an environment with a high prevalence of other causes of anemia.
Gloire MbayaboPaul Lumbala KabuyiMamy NgoleAimé Z LumakaValerie RaceDiane MaisinDamien GrusonGert MatthijsTite Mikobi MingaKoenraad DevriendtChris Van GeetProsper Lukusa TshiloboPublished in: Journal of clinical laboratory analysis (2022)
This study reveals a high proportion of false-positive SCA diagnoses in a rural environment in Central Africa. This underlines the importance of DNA testing in conjunction with Hb electrophoresis.