Histone Modifications and miRNA Perturbations Contribute to Transcriptional Dysregulation of Hypertrophy in Obstructive Hypertrophic Cardiomyopathy.

Ramin GarmanySurendra DasariJ Martijn BosEvelyn T KimDavid J TesterCristobal Dos RemediosJoseph J MaleszewskiKeith D RobertsonJoseph A DearaniSteve R OmmenJohn R GiudicessiMichael J Ackerman

Published in: bioRxiv : the preprint server for biology (2024)

Myectomy tissue from patients with obstructive HCM shows transcriptional dysregulation, including transcriptional downregulation of hypertrophy pathways mediated by miRNA and post-translational modifications of histones. Cardiac hypertrophy loci showed activation via changes in H3K9ac and a mix of activation and repression via H3K27ac.

Keyphrases

hypertrophic cardiomyopathy
left ventricular
gene expression
transcription factor
heat shock
dna methylation
signaling pathway
cell proliferation
heart failure
oxidative stress
genome wide association study