Effect of intermittent inspiratory leaks on measurement of lung clearance index using nitrogen and sulfur hexafluoride.

Even small air leaks can have a significant impact on LCI measured using N2. This is particularly the case for leaks that occur towards the end of washout. In contrast, leaks generally have a much smaller impact on LCI measured by SF6. http://ow.ly/az7b30lG5Ku.