Login / Signup

Chronic myeloid leukemia with pure erythroid leukemia blast crisis.

Jeremy W JacobsRahul RamaswamyVanessa StatesJennifer ReppucciOlalekan O OluwoleEmily F MasonMary Ann Thompson
Published in: Leukemia & lymphoma (2021)
Chronic myeloid leukemia (CML), a myeloproliferative neoplasm defined by the presence of the BCR-ABL1 oncogene created by the reciprocal translocation t(9;22)(q34.1;q11.2), can often be controlled by medications that inhibit this constitutive tyrosine kinase. However, if these therapies fail, the disease may progress to a form resembling an acute leukemia. While most of these CML 'blast crises' are characterized by blasts with a myeloid (granulocytic) or lymphoid lineage, these blasts may rarely be predominantly erythroid. Cases of CML erythroid blast crises have been reported; however, secondary pure erythroid leukemia arising from a CML blast crisis has only been definitively reported once before. We report the second definitive case of pure erythroid leukemia with the t(9;22)(q34.1;q11.2) presenting as a CML blast crisis and characterize the morphologic, immunophenotypic, flow cytometric, cytogenetic, and molecular findings.
Keyphrases
  • chronic myeloid leukemia
  • tyrosine kinase
  • acute myeloid leukemia
  • bone marrow
  • public health
  • epidermal growth factor receptor
  • radiation therapy
  • immune response
  • high grade
  • single molecule
  • rectal cancer