Physiologically Based Pharmacokinetic Modelling to Identify Pharmacokinetic Parameters Driving Drug Exposure Changes in the Elderly.

Felix StaderHannah KinvigMelissa A PennyManuel BattegayMarco SiccardiCatia Marzolini

Published in: Clinical pharmacokinetics (2021)

The progressive decrease in hepatic and renal blood flow, as well as glomerular filtration, rate led to a reduced clearance driving exposure changes in the healthy elderly, independent of the drug.

Keyphrases

blood flow
middle aged
community dwelling
multiple sclerosis
drug induced
emergency department