Catalytic Generation of C1 Ammonium Enolates from Halides and CO for Asymmetric Cascade Reactions.
Lu-Lu LiDu DingJin SongZhi-Yong HanLiu-Zhu GongPublished in: Angewandte Chemie (International ed. in English) (2019)
A general strategy for the design of asymmetric cascade reactions using readily available halides and carbon monoxide (CO) as substrates is developed. The key is the catalytic generation of C1-ammonium enolates for the subsequent asymmetric cascade reactions through the combination of palladium-catalyzed carbonylation and chiral Lewis base catalysis. Utilizing this strategy, we have established asymmetric formal [1+1+4] and [1+1+2] reactions to afford chiral dihydropyridones and β-lactams with high yields and high enantio- and diastereoselectivities.
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