Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck.

I-Tsu ChyuanHsiu-Jung LiaoTse-Hua TanHuai-Chia ChuangYu-Chuan ChuMeng-Hsun PanChien-Sheng WuChing-Liang ChuBor-Ching SheuPing-Ning Hsu

Published in: Journal of biomedical science (2024)

TRAIL-R associates with phosphatase SHP-1 and transduces a unique and distinct immune gatekeeper signal to repress TCR signaling and T cell activation via inactivating Lck. Thus, our results define TRAIL-R as a new class of immune checkpoint receptors for restraining T cell activation, and TRAIL-R/SHP-1 axis can serve as a potential therapeutic target for immune-mediated diseases.

Keyphrases

regulatory t cells
immune response
risk assessment
protein kinase
human health