The Transition From a Compensatory Increase to a Decrease in C-peptide During the Progression to Type 1 Diabetes and Its Relation to Risk.
Heba M IsmailDavid CuthbertsonStephen E GitelmanJay S SkylerAndrea K SteckHenry RodriguezMark AtkinsonBrandon M NathanMaria J RedondoKevan C HeroldCarmella Evans-MolinaLinda A DiMeglioJay Sosenkonull nullPublished in: Diabetes care (2022)
A transition from an increase to a decrease in AUC C-peptide ∼1.5 years prediagnosis was validated in two independent cohorts. The median Index60 value at that time point can be used as a pathophysiologic-based threshold for identifying individuals at high risk for T1D.