A novel tool for arrhythmic risk stratification in desmoplakin gene variant carriers.
Richard T CarrickAlessio GasperettiAlexandros ProtonotariosBrittney MurrayMikael LaredoIris van der SchaafDennis DooijesPetros SyrrisDouglas E CannieCrystal TichnellNisha A GilotraChiara CappellettoKristen MedoArdan Muammer SagunerFirat DuruRobyn J HylindDominic J AbramsNeal K LakdawalaJulia Cadrin-TourignyMattia TargettiIacopo OlivottoMaddalena GraziosiMoniek G P J CoxElena BiaginiPhilippe CharronPaolo CompagnucciMichela CasellaGiulio ConteClaudio TondoMomina YazdaniJames S WareSanjay K PrasadLeonardo CalòEric D SmithAdam S HelmsSophie HespeJodie InglesHarikrishna TandriFlavie AderGiovanni PerettoStacey PetersAri HortonJessica YaoEric Schulze-BahrSven DittmanEric D CarruthKatelyn YoungMaria QureshiChris HaggertyVictoria N ParikhMatthew TaylorLuisa MestroniArthur WildeGianfranco SinagraMarco MerloEstelle GandjbakhchJ Peter van TintelenAnneline S J M Te RielePerry ElliotHugh CalkinsKatherine C WuCynthia A JamesPublished in: European heart journal (2024)
The DSP risk score is a novel model that leverages readily available clinical parameters to provide individualized VA risk assessment for DSP patients. This tool may help guide decision-making for primary prevention implantable cardioverter-defibrillator placement in this high-risk population and supports a gene-first risk stratification approach.