A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity.

Xujia WuSonghua XiaoMaolei ZhangLixuan YangJian ZhongBo LiFanying LiXin XiaXixi LiHuangkai ZhouDawei LiuNunu HuangXuesong YangFeizhe XiaoNu Zhang

Published in: Genome biology (2021)

Our study reveals that SMO-193a.a., a novel protein encoded by circular SMO, is critical for Hedgehog signaling, drives glioblastoma tumorigenesis and is a novel target for glioblastoma treatment.

Keyphrases

protein protein
binding protein
small molecule