Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-8058.

So-Ichiro KimuraYoshihiro WatanabeYudai MikasaRei MiyanoToshiyuki TokiwaKenichi NonakaTakuji NakashimaYoshihiko Noguchi Tomoyasu HiroseToshiaki SunazukaRei HokariAki Ishiyama Masato Iwatsuki

Published in: The Journal of antibiotics (2024)

Two new pramanicin analogs, named virgaricins C (1) and D (2), were discovered by physicochemical screening from a static cultured material of Apiospora sp. FKI-8058. Their structures were elucidated by MS and NMR analyses and chemical derivatization. Compounds 1 and 2 showed moderate antimalarial activity and cytotoxicity.

Keyphrases

ms ms
high resolution
molecular docking
mass spectrometry
magnetic resonance
multiple sclerosis
high performance liquid chromatography
liquid chromatography tandem mass spectrometry
liquid chromatography
high intensity
tandem mass spectrometry
solid state
solid phase extraction