Internalisation of immunoglobulin light chains by cardiomyocytes in AL amyloidosis: what can biopsies tell us?

Mélanie BézardAmira ZarouiMounira KharoubiFrance LamElsa PoullotEmmanuel TeigerOnnik AgbulutThibaud DamyEkaterini Kordeli

Published in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2024)

Internalisation of LCs occurs in patient cardiomyocytes. This event could have important consequences for the pathogenesis of the cardiac disease by enabling interactions between amyloid molecules and cellular organelles inducing specific signalling pathways, and might bring new insight regarding treatment.

Keyphrases

case report
left ventricular
high glucose
endothelial cells
atrial fibrillation
smoking cessation