Increased Postoperative Opioid Consumption in the Presence of Co-administration of 5-HT3 Antagonists with Acetaminophen: A Hospital Registry Study.

Nikolai RatajczakRicardo Munoz-Acuna Simone Redaelli Aiman M Suleiman Eva-Lotte Seibold Dario von Wedel Denys ShaySarah AshrafianGuanqing Chen Eswar Sundar Elena AhrensLuca J WachtendorfMaximilian S Schaefer

Published in: Anesthesiology (2024)

A dose-dependent association of pre- or intraoperative acetaminophen with decreased postoperative opioid consumption was not observed when 5-HT3 antagonists were co-administered, suggesting that physicians might consider reserving 5-HT3 antagonists as rescue medication for postoperative nausea or vomiting when acetaminophen is administered for pain prophylaxis.

Keyphrases

chronic pain
patients undergoing
pain management
liver injury
healthcare
primary care
chemotherapy induced
adverse drug
neuropathic pain
spinal cord
acute care