Safety, pharmacokinetics, and pharmacodynamics of panobinostat in children, adolescents, and young adults with relapsed acute myeloid leukemia.

Seth E KarolTodd M CooperPaul E MeadKristine R CrewsJohn C PanettaThomas B AlexanderJeffrey W TaubNorman J LacayoKenneth M HeymDennis John KuoDeborah E SchiffDeepa BhojwaniYubin GeJeffery M KlcoRaul C RibeiroHiroto Inaba Ching-Hong Pui Jeffrey E Rubnitz

Published in: Cancer (2020)

Panobinostat can be safely administered with chemotherapy and results in increased blast histone acetylation. This suggests that it should be further studied in AML.

Keyphrases

acute myeloid leukemia
histone deacetylase
young adults
allogeneic hematopoietic stem cell transplantation
dna methylation
physical activity
locally advanced
middle aged
acute lymphoblastic leukemia
gene expression
squamous cell carcinoma
solid state