Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus.

Xiao-Hong LiRicardo DeMarcoLeandro Xavier NevesSally R JamesKatherine NewlingPeter D AshtonJian-Ping CaoR Alan WilsonWilliam Castro-Borges

Published in: PLoS neglected tropical diseases (2018)

The mixture of approximately 40 proteins specifically secreted by the esophageal glands is responsible for initiating blood processing in the adult worm esophagus. They comprise the potential targets for the self-cure process in the rhesus macaque, and thus represent a completely new cohort of secreted proteins that can be investigated as vaccine candidates.

Keyphrases

gene expression
transcription factor
genome wide
copy number
human health
heat shock
mass spectrometry
high speed