KRAS and NRAS mutational gene profile of metastatic colorectal cancer patients in Jordan.
Muhammad AwidiNidaa AbabnehMaha ShomafFeras Al FararjehLaila OwaidiMohammad AlKhatibButhaina Al TarawnehAbdalla AwidiPublished in: PloS one (2019)
The frequency of NRAS and KRAS mutations outside of exon 2 appears to be higher in Jordanian patients in comparison with patients from western countries. KRAS mutations outside of exon 2 should be tested routinely to identify patients who should not be treated with anti-EGFR antibodies.