AQP3-mediated activation of the AMPK/SIRT1 signaling pathway curtails gallstone formation in mice by inhibiting inflammatory injury of gallbladder mucosal epithelial cells.

Ganggang WangHao ZhangZhijie ZhouWenzhi JinXin ZhangZenghui MaXiaoliang Wang

Published in: Molecular medicine (Cambridge, Mass.) (2023)

Data from our study highlight the inhibitory role of AQP3 in gallbladder damage and gallstone formation in mice by reducing inflammatory injury of gallbladder mucosal epithelial cells, which is achieved through activation of the AMPK/SIRT1 signaling pathway.

Keyphrases

signaling pathway
oxidative stress
pi k akt
high fat diet induced
induced apoptosis
epithelial mesenchymal transition
skeletal muscle
ischemia reperfusion injury
ulcerative colitis
protein kinase
wild type
type diabetes
insulin resistance
big data
deep learning
endoplasmic reticulum stress