Clozapine N-oxide, compound 21, and JHU37160 do not influence effortful reward-seeking behavior in mice.

Yoshiatsu Aomine Yoshinobu Oyama Koki Sakurai Tom Macpherson Takaaki Ozawa Takatoshi Hikida

Published in: Psychopharmacology (2023)

This study provides definitive evidence that commonly used doses of CNO, C21, and J60 have negligible off-target effects on motivated reward-seeking but urges caution when using high doses of J60 due to sedative effects.

Keyphrases

mental health
high fat diet induced
type diabetes
metabolic syndrome
adipose tissue