Hyperlipidemia and Obesity's Role in Immune Dysregulation Underlying the Severity of COVID-19 Infection.
Christopher KhatchadourianChristina SisliyanKevin NguyenNicole PoladianQi TianFaraaz TamjidiBao LuongManpreet SinghJeremiah RobisonVishwanath VenketaramanPublished in: Clinics and practice (2021)
Obesity and hyperlipidemia are known to be risk factors for various pathological disorders, including various forms of infectious respiratory disease, including the current Coronavirus outbreak termed Coronavirus Disease 19 (COVID-19). This review studies the effects of hyperlipidemia and obesity on enhancing the inflammatory response seen in COVID-19 and potential therapeutic pathways related to these processes. In order to better understand the underlying processes of cytokine and chemokine-induced inflammation, we must further investigate the immunomodulatory effects of agents such as Vitamin D and the reduced form of glutathione as adjunctive therapies for COVID-19 disease.
Keyphrases
- coronavirus disease
- high fat diet induced
- sars cov
- insulin resistance
- metabolic syndrome
- weight loss
- high fat diet
- respiratory syndrome coronavirus
- inflammatory response
- type diabetes
- weight gain
- oxidative stress
- adipose tissue
- skeletal muscle
- drug induced
- diabetic rats
- physical activity
- lipopolysaccharide induced
- lps induced
- stress induced