Targeting 8-oxoguanine DNA glycosylase-1 (OGG1 ) as a therapeutic strategy in inflammatory-related diseases.

Abdullahi Samaila Rusliza Basir Mukhtar Gambo Lawal Razif Abas Maizaton Atmadini Abdullah Roslaini Abd Majid Norshariza Binti Nordin Mohd Khairi Hussain Nur Izah Ab Razak Yoke Keong Yong Basiru Aliyu

Published in: Immunopharmacology and immunotoxicology (2024)

the 8-oxo/OGG1 pathway and its role in inflammation and inflammatory disease conditions. Due to the paucity of studies involving OGG1in inflammatory infectious diseases, further research projects are needed to explore the therapeutic potential of various OGG1 inhibitors to serve as novel therapeutic strategies in infectious inflammatory diseases of medical importance in developing countries such as malaria, meningitis, tuberculosis among others.

Keyphrases

dna repair
oxidative stress
infectious diseases
dna damage
healthcare
mycobacterium tuberculosis
cancer therapy
single molecule
hiv infected
human immunodeficiency virus
case control
antiretroviral therapy
nucleic acid
drug induced