Peripartum hyperhemolysis prophylaxis and management in sickle cell disease: A case report and narrative review.
Lakshman VasanthamohanSheryl ChooTonisha MarshallYahui Tammy SymonsDoreen MatsuiGenevieve EastabrookZiad SolhPublished in: Transfusion (2020)
This is the first published case of HS prophylaxis in a pregnant SCD patient, with good maternal and fetal outcomes after transfusion. HU and ESAs were able to control SCD and mitigate anemia in lieu of prophylactic transfusions during pregnancy. Further prospective studies are necessary to elucidate the ideal management of pregnant SCD patients with a history of HS or other contraindications to chronic transfusion.