Patient-specific iPSC-derived cardiomyocytes reveal aberrant activation of Wnt/β-catenin signaling in SCN5A-related Brugada syndrome.

Dongsheng CaiXiaochen WangYaxun SunHangping FanJingjun ZhouZongkuai YangHangyuan QiuJue WangJun SuTingyu GongChenyang JiangPing Liang

Published in: Stem cell research & therapy (2023)

Our findings suggest that aberrant activation of Wnt/β-catenin signaling contributes to the pathogenesis of SCN5A-related BrS and point to Wnt/β-catenin as a potential therapeutic target.

Keyphrases

cell proliferation
stem cells
epithelial mesenchymal transition
single cell
case report
risk assessment
dna methylation
human health
signaling pathway
induced pluripotent stem cells