Patient-specific iPSC-derived cardiomyocytes reveal aberrant activation of Wnt/β-catenin signaling in SCN5A-related Brugada syndrome.
Dongsheng CaiXiaochen WangYaxun SunHangping FanJingjun ZhouZongkuai YangHangyuan QiuJue WangJun SuTingyu GongChenyang JiangPing LiangPublished in: Stem cell research & therapy (2023)
Our findings suggest that aberrant activation of Wnt/β-catenin signaling contributes to the pathogenesis of SCN5A-related BrS and point to Wnt/β-catenin as a potential therapeutic target.