The interplay of KRAS mutational status with tumor laterality in non-metastatic colorectal cancer: An international, multi-institutional study in patients with known KRAS, BRAF, and MSI status.
Carsten KamphuesShigenori KadowakiNeda AminiInge van den BergJaeyun WangNikolaos AndreatosYuki SakamotoToshiro OguraMiho KakutaAnastasia PikouliDespoina GekaNobuya DaitokuMaria TheochariStefan BuettnerTakahiko AkiyamaEfstathios AntoniouEmmanouil PikoulisGeorge TheodoropoulosKatsunori ImaiJan N M IjzermansGeorgios A MargonisKiwamu AkagiMartin E KreisPublished in: Journal of surgical oncology (2020)
KRAS mutation status was independently prognostic among patients with LS tumors, but this association failed to reach statistical significance in RS and rectal tumors. These findings confirm reports in metastatic CRC and underline the possible biologic importance of tumor location.