Ectoderm-derived frontal bone mesenchymal stem cells promote traumatic brain injury recovery by alleviating neuroinflammation and glutamate excitotoxicity partially via FGF1.
Qiaozhen QinTing WangZhenhua XuShuirong LiuHeyang ZhangZhangzhen DuJianing WangYadi WangZhenning WangShanshan YuanJiamei WuWenyan HeChangzhen WangXinlong YanYan WangXiao-Xia JiangPublished in: Stem cell research & therapy (2022)
Ectoderm-derived FbMSC application significantly alleviated neuroinflammation, brain injury, and excitatory toxicity to neurons, improved cognition and behavioral deficits in TBI mice. Therefore, ectoderm-derived FbMSCs could be ideal therapeutic candidates for TBI which mostly affect cells from the same embryonic origins as FbMSCs.
Keyphrases
- traumatic brain injury
- brain injury
- mesenchymal stem cells
- subarachnoid hemorrhage
- severe traumatic brain injury
- cerebral ischemia
- oxidative stress
- spinal cord
- bone marrow
- lipopolysaccharide induced
- umbilical cord
- bone mineral density
- adipose tissue
- functional connectivity
- blood brain barrier
- metabolic syndrome
- type diabetes
- lps induced
- inflammatory response
- soft tissue
- bone loss