Early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes.

Wai Ping YewNatalia D DjukicJaya S P JayaseelanFrederick R WalkerKarl A A RoosTimothy K ChatawayHakan MuydermanNeil R Sims

Published in: Journal of neuroinflammation (2019)

Early post-stroke treatment with minocycline improved recovery but had little effect on key features of microglial activation. Both the decrease in CD68-positive cells and the increased activation of astrogliosis could influence neuronal plasticity and contribute to the improved recovery.

Keyphrases

induced apoptosis
atrial fibrillation
heart failure
cell cycle arrest
acute coronary syndrome
spinal cord
cell death
spinal cord injury
signaling pathway
smoking cessation
nk cells