A novel coordination complex of platinum (PT) induces cell death in colorectal cancer by altering redox balance and modulating MAPK pathway.

Khayal Al-KhayalMansoor-Ali Vaali-MohammedMohammed ElwatidyThamer Bin TraikiOmar Al-ObeedMohammad AzamZahid KhanMaha AbdullaRehan Ahmad

Published in: BMC cancer (2020)

Collectively, our data demonstrates that the platinum complex (PT) exerts its anti-proliferative effect on CRC by ROS-mediated apoptosis and activating p38 MAPK pathway. Thus, our findings reveal a novel mechanism of action for PT on colorectal cancer cells and may have therapeutic implication.

Keyphrases

cell death
signaling pathway
oxidative stress
dna damage
electronic health record
pi k akt
cell cycle arrest
single cell
big data
gene expression
cell proliferation
deep learning
electron transfer