Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer.

Xin GuanRuiqi LiuBojun WangRuxin XiongLuying CuiYuanyu LiaoYuli RuanLin FangXiaolin LuXuefan YuDan SuYue MaTianjiao DangZhuo ChenYuanfei YaoChao LiuYan-Qiao Zhang

Published in: Clinical and translational medicine (2024)

Silencing of NLRP3 limits the GSDMD-dependent pyroptosis in colorectal cancer. HDAC2-mediated histone deacetylation leads to epigenetic silencing of NLRP3. HDAC2 suppresses the NLRP3 transcription by inhibiting the formation of H3K27ac/BRD4/p-P65 complex. Targeting HDAC2 activates pyroptosis and enhances therapeutic effect.

Keyphrases

nlrp inflammasome
histone deacetylase
dna methylation
signaling pathway
transcription factor
smoking cessation