Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors.
Arnon Møldrup KnudsenBo HalleOriane CédileMark BurtonChristina BaunHelge ThisgaardAtul AnandChristopher HubertMads ThomassenSigne Regner MichaelsenBirgitte Brinkmann OlsenRikke Hedegaard DahlrotRolf BjerkvigJustin Durla LathiaBjarne Winther KristensenPublished in: Neuro-oncology (2022)
Surgical tumor resection is an iatrogenic driver of PTN-mediated self-renewal in glioblastoma tumor cells that promotes therapeutic resistance and tumor recurrence.
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