Prospective evaluation of the limitations of near-infrared imaging in detecting axillary sentinel lymph nodes in primary breast cancer.
Chafika MazouniMeriem KoualFrederic De LeeuwAngelica ConversanoNicolas LeymarieFrançoise RimareixHeba AlkhashnamCorinne Laplace-BuilhéMuriel AbbaciPublished in: The breast journal (2018)
We compared the performance of near-infrared imaging using indocyanine green (ICG) with the radioisotope (ISO) method to detect sentinel lymph nodes (SLNs) in breast cancer, to analyze predictive factors for negative ICG identification. The study included 122 patients who underwent sentinel lymph node biopsy (SLNB) using the combined ISO and ICG technique for primary breast cancer. We assessed the putative association between pathologic/clinical variables and ICG failure to detect SLNs. The ISO identification rate was 96.7% and ICG identification 81.9%. Overweight patients or presence of macrometastasis in SLNB were associated with the risk of ICG failing to detect SLNs (P = 0.02).
Keyphrases
- lymph node
- fluorescence imaging
- sentinel lymph node
- end stage renal disease
- neoadjuvant chemotherapy
- ejection fraction
- chronic kidney disease
- prognostic factors
- high resolution
- early stage
- peritoneal dialysis
- squamous cell carcinoma
- ultrasound guided
- body mass index
- bioinformatics analysis
- patient reported
- locally advanced