Quantitative Susceptibility Mapping in Parkinson's Disease.

Christian LangkammerLukas PirpamerStephan SeilerAndreas DeistungFerdinand SchweserSebastian FranthalNina HomayoonPetra Katschnig-WinterMariella Koegl-WallnerTamara PendlEva Maria StoegererKaroline WenzelFranz FazekasStefan RopeleJürgen Rainer ReichenbachReinhold SchmidtPetra Schwingenschuh

Published in: PloS one (2016)

The established finding of higher R2* rates in the substantia nigra was extended by QSM showing superior sensitivity for PD-related tissue changes in nigrostriatal dopaminergic pathways. QSM additionally reflected the levodopa-dosage and disease severity. These results suggest a more widespread pathologic involvement and QSM as a novel means for its investigation, more sensitive than current MRI techniques.

Keyphrases

high resolution
magnetic resonance imaging
parkinson disease
contrast enhanced
neoadjuvant chemotherapy
deep brain stimulation
computed tomography
magnetic resonance
diffusion weighted imaging
lymph node