Roles of FoxM1-driven basal β-cell proliferation in maintenance of β-cell mass and glucose tolerance during adulthood.
Masato KohataJunta ImaiTomohito IzumiJunpei YamamotoYohei KawanaAkira EndoHiroto SugawaraJunro SeikeHaremaru KuboHiroshi KomamuraToshihiro SatoShinichiro HosakaYuichiro MunakataYoichiro AsaiShinjiro KodamaKei TakahashiKeizo KanekoHideki KatagiriPublished in: Journal of diabetes investigation (2022)
Basal low-level proliferation of β-cells during adulthood is important for maintaining sufficient β-cell mass and good glucose tolerance and β-cell FoxM1 underlies this mechanism. Preserving β-cell FoxM1 activity may prevent the impairment of glucose tolerance with advancing age.