IL-17 polarization of MAIT cells is derived from the activation of two different pathways.

Giuliana GugginoDiana Di LibertoMarianna Lo PizzoLaura SaievaRiccardo AlessandroFrancesco DieliGiovanni TrioloFrancesco Ciccia

Published in: European journal of immunology (2018)

MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome.

Keyphrases

induced apoptosis
cell cycle arrest
signaling pathway
oxidative stress
cell death
case report
pi k akt