Dapagliflozin Attenuates Sympathetic and Pressor Responses to Stress in Young Prehypertensive Spontaneously Hypertensive Rats.

Han-Kyul KimRie IshizawaAyumi FukazawaZhongyun WangUrsa Bezan PetricMing Chang HuScott A Smith Masaki Mizuno Wanpen Vongpatanasin

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

These data demonstrate a novel role for SGLT2i in reducing resting BP as well as the activity of skeletal muscle reflexes, independent of glycemic control. Our study may have important clinical implications for preventing hypertension and hypertensive heart disease in young prehypertensive individuals.

Keyphrases

glycemic control
skeletal muscle
blood pressure
type diabetes
insulin resistance
heart rate
blood glucose
middle aged
weight loss
electronic health record
big data
adipose tissue
deep learning
artificial intelligence