Analytical Study of the Antifungal Posaconazole in Raw Material: Quantitative Bioassay, Decomposition Chemical Kinetics, and Degradation Impurities by LC-QTOF-MS.

Cássia Virginia GarciaAndressa S BitencourtSendy S OliveiraCaren GobettiAndreas S L Mendez

Published in: Journal of AOAC International (2021)

A microbiological bioassay was developed for posaconazole, first-order kinetics was determined for photolytic degradation, and structures for new degradation products were suggested.

Keyphrases

ms ms
mass spectrometry
high resolution
liquid chromatography
candida albicans
tandem mass spectrometry
solid phase extraction