Erythropoietin Slows Photoreceptor Cell Death in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa.
Tonia S RexLorraine KasmalaWesley S BondAna M de Lucas CerrilloKristi WynnAlfred S LewinPublished in: PloS one (2016)
Systemic EPO-R76E slows death of the photoreceptors and vision loss in hP23H RHO+/-,mRHO+/+ mice. Treatment with EPO-R76E may widen the therapeutic window for retinal degeneration patients by increasing the number of viable cells. Future studies might investigate if co-treatment with EPO-R76E and gene replacement therapy is more effective than gene replacement therapy alone.
Keyphrases
- replacement therapy
- smoking cessation
- cell death
- mouse model
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- genome wide
- copy number
- cell cycle arrest
- type diabetes
- prognostic factors
- gene expression
- diabetic retinopathy
- current status
- peritoneal dialysis
- oxidative stress
- transcription factor
- endoplasmic reticulum stress
- case control