Histomorphology and immunohistochemical patterns in degenerative disc disease and clinical-radiological correlations: a prospective study.
Massimo MiscusiCristina CarnevaliLuca RicciardiSelenia MigliettaVincenzo PetrozzaJessica CacciottiAntonella CalogeroPaolo RosaGiuseppe FamiliariAntonino RacoPublished in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2020)
The discs with Modic I MRI signal could represent potential targets for medical treatments, whereas Modic II seems to be a more likely point of no return in a degenerative process. Therefore, further investigations are to better investigate inflammatory pathways and degenerative mechanisms in DDD.