Increased prevalence of multiple sclerosis and clusters of different disease risk in Northern Italy.

Roberto BergamaschiMaria Cristina MontiLeonardo TrivelliVincenzo Paolo IntrocasoGiulia MallucciPaola BorrelliLeonardo GerosaCristina Montomoli

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2019)

The current MS prevalence sets the province of Pavia among high-risk areas and, compared with the previous prevalence estimate (86 per 100,000 in year 2000), indicates an increased MS risk. The Bayesian mapping highlighted area with a significantly higher/lower MS risk where to investigate etiologic hypotheses based on environmental and genetic exposures.

Keyphrases

multiple sclerosis
mass spectrometry
risk factors
ms ms
high resolution
air pollution
gene expression
white matter
risk assessment
genome wide
climate change
high density