Multilayered Cell Sheets of Cardiac Reprogrammed Cells for the Evaluation of Drug Cytotoxicity.

Sung Pil KwonSeuk Young SongJin YooHan Young KimJu-Ro LeeMikyung KangHee Su SohnSeokhyoung GoMungyo JungJihye HongSonghyun LimCheesue KimSangjun MoonKookheon CharByung-Seok Kim

Published in: Tissue engineering and regenerative medicine (2021)

The layer number of cardiac-mimetic cell sheets affects drug cytotoxicity outcomes in drug toxicity tests. The in vitro cellular configuration that more closely mimics the in vivo configuration in the evaluation systems seems to exhibit lower cytotoxicity in response to drug.

Keyphrases

single cell
cell therapy
left ventricular
adverse drug
induced apoptosis
drug induced
stem cells
type diabetes
adipose tissue
heart failure
mesenchymal stem cells
signaling pathway
bone marrow
endoplasmic reticulum stress
glycemic control