Optimizing the timing of highest hydrocortisone dose in children and adolescents with 21-hydroxylase deficiency.
Mariska A M SchröderAntonius E van HerwaardenPaul N SpanErica L T van den AkkerGianni BoccaSabine Elisabeth HannemaHetty J van der KampSandra W K de KortChristiaan F MooijDina A SchottSaartje StraetemansVera van TellingenJaniëlle A van der VeldenFred C G J SweepHedi L Claahsen van der GrintenPublished in: The Journal of clinical endocrinology and metabolism (2021)
No clear benefit for either treatment schedule was established. Given the variation in individual responses we recommend to individually optimize dose distribution and monitoring disease control at multiple timepoints.
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