Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs.

Anna A KiselevaVladislav A KorobeynikovAnna S NikonovaPeishan ZhangPetr MakhovAlexander Y DenekaMargret B EinarsonIlya G SerebriiskiiHanqing Liu Jeffrey R Peterson Erica A Golemis

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

These results suggest a paradigm by which targeted drugs may have unexpected off-target effects in heterogeneous cell populations in vivo via control of a physical platform for receipt of extracellular ligands.

Keyphrases

cancer therapy
single cell
physical activity
mental health
cell therapy
drug induced
stem cells
mesenchymal stem cells