HBV preS deletion mapping using deep sequencing demonstrates a unique association with viral markers.
Yuichiro SuzukiShinya MaekawaNobutoshi KomatsuMitsuaki SatoAkihisa TatsumiMika MiuraShuya MatsudaMasaru MuraokaNatsuko NakakukiFumitake AmemiyaShinichi TakanoMitsuharu FukasawaYasuhiro NakayamaTatsuya YamaguchiTaisuke InoueTadashi SatoMinoru SakamotoAtsuya YamashitaKohji MoriishiNobuyuki EnomotoPublished in: PloS one (2019)
The preS codon.132-141 deletions have a significant influence on the clinical characteristics and viral markers, even when present as a minor population. Importantly, the preS codon 132-141 deletions have a clear influence on the viral life cycle and pathogenesis.
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