Pain-autonomic interaction: A surrogate marker of central sensitization.

Paulina Simonne ScheurenJan RosnerArmin CurtMichèle Hubli

Published in: European journal of pain (London, England) (2020)

Our findings provide evidence that combined recordings of sympathetic skin responses (SSRs) and pinprick evoked potentials (PEPs) might be able to unmask central sensitization induced through a well-established experimental pain model in healthy individuals. As such, these novel readouts of central sensitization might attain new insights towards complementing clinical pain phenotyping.

Keyphrases

chronic pain
pain management
neuropathic pain
high throughput
heart rate variability
spinal cord
blood pressure
postoperative pain
endothelial cells