Eplerenone reduces renal ischaemia/reperfusion injury by modulating Klotho, NF-κB and SIRT1/SIRT3/PGC-1α signalling pathways.

Alireza BaratiYalda Rahbar SaadatSeyed Mohammadmahdi MeybodiSana NouraeiKimia MoradiFarid Kamrani MoghaddamZahra MalekinejadSeyed Mahdi Hosseiniyan KhatibiSepideh Zununi VahedYasin Bagheri

Published in: The Journal of pharmacy and pharmacology (2022)

The results recommended that Eplerenone exerts a protective effect against kidney IR injury by up-regulating Klotho, HSP70, sirtuins and PGC-1α to preserve mitochondrial function and cell survival. Moreover, it hinders renal inflammation by suppressing NF-κB signalling. These results offer insight into the prevention or treatment of AKI in the future.

Keyphrases

oxidative stress
signaling pathway
skeletal muscle
lps induced
pi k akt
ischemia reperfusion injury
acute kidney injury
heat shock protein
acute myocardial infarction
heat shock
current status
cerebral ischemia
heart failure
combination therapy
acute ischemic stroke
coronary artery disease
blood brain barrier