Gene-environment analyses in a UK Biobank skin cancer cohort identifies important SNPs in DNA repair genes that may help prognosticate disease risk.

Richie Jeremian Pingxing Xie Misha Fotovati Philippe Lefraçnois Ivan V Litvinov

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2023)

This study revealed genome-wide associations with important implications for understanding skin cancer risk in the context of the rapidly-evolving field of precision medicine. Major individual factors (including sex, hair and skin color, and sun protection use) were significant mediators for all skin cancers, interacting with >200 SNPs across four skin cancer types.

Keyphrases

genome wide
skin cancer
dna repair
dna methylation
soft tissue
copy number
wound healing
dna damage
dna damage response
gene expression