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Phosphatidic acid: a lipid regulator of the Hippo pathway.

Han HanRebecca VargasGayoung SeoWenqi Wang
Published in: Molecular & cellular oncology (2018)
The Hippo pathway, a signaling pathway highly conserved across species, plays a crucial role in organ size control and cancer suppression. Our recent study shows that phosphatidic acid can regulate the Hippo pathway through a physical lipid-protein interaction, providing additional insights into the Hippo-related tissue homeostasis and cancer development.
Keyphrases
  • papillary thyroid
  • signaling pathway
  • squamous cell
  • transcription factor
  • mental health
  • epithelial mesenchymal transition
  • small molecule
  • protein protein
  • endoplasmic reticulum stress
  • genetic diversity