Sub-10 nm Sr2LuF7:Yb/Er@Sr2GdF7@SrF2 Up-Conversion Nanocrystals for Up-Conversion Luminescence-Magnetic Resonance-Computed Tomography Trimodal Bioimaging.
Cailing ChenJianhua LiuYing ChenChunguang LiXiaomin LiuHe HuangChen LiangYue LouZhan ShiShouhua FengPublished in: ACS applied materials & interfaces (2017)
Herein, sub-10 nm core-shell nanocrystals (NCs), which select Sr2LuF7:Yb/Er as core, Sr2GdF7 as middle shell, and SrF2 as an outermost shell, were synthesized by a seed-mediated growth process. The NCs possess good crystallinity, morphology, and up-conversion luminescent properties. After modification by polyethylenimine branched (PEI), in vitro cell up-conversion imaging with low autofluorescence was realized. Due to the presence of Gd3+ ions, in vivo magnetic resonance (MR) imaging was also achieved with these designed NCs. More significantly, these special core-shell NCs exhibited high contrast in in vivo X-ray computed tomography (CT) imaging because of their good X-ray absorption ability. These results indicate that the core-shell up-conversion NCs can serve as promising contrast agents for up-conversion luminescence-MR-CT trimodal bioimaging.
Keyphrases
- contrast enhanced
- magnetic resonance
- computed tomography
- dual energy
- quantum dots
- energy transfer
- magnetic resonance imaging
- high resolution
- image quality
- positron emission tomography
- photodynamic therapy
- stem cells
- room temperature
- endoplasmic reticulum
- sensitive detection
- mass spectrometry
- single cell
- mesenchymal stem cells
- single molecule